Advances in the role of CD4+T cells in autoimmune uveitis
10.3980/j.issn.1672-5123.2025.12.08
- VernacularTitle:CD4+T细胞在自身免疫性葡萄膜炎中的研究进展
- Author:
Xinghua HUANG
1
;
Houjiao CHEN
1
;
Yingcheng LIN
1
;
Jinqing LIU
1
;
Shuyang ZHONG
1
Author Information
1. Guangxi University of Chinese Medicine, Nanning 530220, Guangxi Zhuang Autonomous Region, China; Department of Ophthalmology, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China
- Publication Type:Journal Article
- Keywords:
CD4+T cells;
autoimmune uveitis;
Th1 cell/Th2 cell;
Th17 cell/Treg cell;
pathogenesis
- From:
International Eye Science
2025;25(12):1943-1947
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune uveitis is a blinding intraocular inflammation primarily caused by immune dysregulation mediated by CD4+ T cells. CD4+ T cells differentiate into various functional subsets, including Th1, Th2, Th17, and Treg cells. These subsets participate in immune responses and mediate the initiation and resolution of inflammation by secreting different cytokines. This article primarily focuses on the functional characteristics and interplay network of Th1/Th2 and Th17/Treg cells, along with the specific effects of their key secreted cytokines(e.g., IFN-γ, TNF-α, IL-17, IL-10, TGF-β)in driving or suppressing ocular inflammation. The goal is to clarify the fundamental pathogenesis of this disease from the perspective of immune balance. Furthermore, this work explores potential therapeutic targets based on restoring the balance between Th1/Th2 and Th17/Treg, such as modulating the differentiation of specific subsets, blocking key pro-inflammatory cytokines, or enhancing anti-inflammatory functions. This investigation aims to provide a scientific rationale and guidance for optimizing existing diagnostic and therapeutic strategies, as well as developing new immunotherapies(e.g., biological agents, cell therapies).
