Regulation of autophagy on diabetic cataract under the interaction of glycation and oxidative stress
10.3980/j.issn.1672-5123.2025.12.06
- VernacularTitle:糖化与氧化应激交互下自噬对糖尿病性白内障的调控
- Author:
Rong WANG
1
;
Pengfei LI
1
;
Jiawei LIU
1
;
Yuxin DAI
1
;
Mengying ZHOU
1
;
Xiaoxi QIAN
1
;
Wei CHEN
1
;
Min JI
1
Author Information
1. Nantong University, Nantong 226019, Jiangsu Province, China; Eye Research Institute, Affiliated Hospital of Nantong University, Nantong 226006, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
autophagy;
diabetic cataract;
glycative stress;
oxidative stress
- From:
International Eye Science
2025;25(12):1932-1937
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cataract, a prevalent ocular complication of diabetes mellitus, arises from a complex interplay of pathological mechanisms, with oxidative stress and glycation stress playing central roles. Autophagy, a critical cellular self-protection mechanism, sustains intracellular homeostasis by selectively degrading damaged organelles and misfolded proteins, thereby counteracting the detrimental effects of oxidative and glycation stress under hyperglycemic conditions. Emerging evidence indicates a synergistic interaction between glycation stress and oxidative stress, which may exacerbate autophagic dysfunction and accelerate the onset and progression of diabetic cataract. However, the precise molecular mechanisms underlying this relationship remain incompletely understood. This review systematically examines the regulatory role of autophagy inthe pathogenesis of diabetic cataract, with a particular focus on how autophagic impairment influences disease progression under the combined effects of glycation and oxidative stress. By elucidating these mechanisms, the paper aims to provide novel insights into molecular diagnostic approaches and targeted therapeutic strategies for diabetic cataract.
