Clinical Characteristics of Different Motor Phenotypes in Patients with Huntington’s Disease in Southern China
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0618
- VernacularTitle:中国南方地区亨廷顿患者不同运动分型的临床特征
- Author:
Li-shan LIN
1
;
Feng-juan SU
1
;
Teng-teng WU
2
;
Yi-xuan ZENG
3
;
Hua-jing YOU
1
;
Ding-bang CHEN
1
;
Xun-hua LI
1
;
Zhong PEI
1
Author Information
1. Department of Neurology， The First Affiliated Hospital of Sun Yat-sen University， Guangzhou 510080， China
2. Department of Neurology， Zhongshan Hospital of Fudan University， Shanghai 200032， China
3. Department of Neurology， Shenzhen Second People's Hospital， Shenzhen 518035， China
- Publication Type:Journal Article
- Keywords:
Huntington’s disease;
motor phenotype;
treatment;
prognosis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(6):944-949
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore clinical characteristics of different motor phenotypes in patients with Huntington’s disease in southern China for individualized precise treatment. MethodA total of 58 Huntington’s disease （HD） patients were enrolled from Guangzhou Center of Chinese Huntington’s Disease Network （CHDN） from March 2014 to May 2021. United Huntington’s Disease Rating Scale （UHDRS） was used to assess patients’ motor function， mental state， cognition and total functional capacity （TFC）. The differences of clinical characteristics among different motor phenotypes were analyzed by Kruskal-Wallis test. ResultsIn southern China， HD patients showed a predominant mixed-motor phenotype， with 72.41% （42/58） of all cases. The clinical characteristics among different motor phenotypes were different， and the TFC score in hypokinetic-rigidity phenotype was lower than that in choreatic motor phenotype ［8.00 （4.00～11.00） vs 13.00 （11.00～13.00）， P=0.037］. ConclusionThe symptoms of movement disorders in HD patients in southern China are complex. The precise classification of motor phenotype is helpful for the treatment and prognosis of HD.
