The Ability of Two New Anthropometric Indices to Screen Metabolic Associated Fatty Liver Disease among Adults
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0607
- VernacularTitle:2种新型人体测量指标对成人代谢相关脂肪性肝病的筛查能力
- Author:
Jia-lu YANG
1
;
Yan-fang LUO
2
;
Ren-hu SHAN
2
;
Zhi-gang ZUO
3
;
Zhen YU
4
;
Yao-wen ZHU
5
;
Liu-qing LI
5
;
Min XIA
1
Author Information
1. School of Public Health， Sun Yat-sen University， Guangzhou 510080， China
2. Department of Public Health， Nancheng Community Health Service Center， Dongguan 523076， China
3. Department of Health Care， Chashan Community Health Service Center， Dongguan 523381， China
4. Department of General Practice， Chashan Community Health Service Center， Dongguan 523381， China
5. Department of Public Health， Dongcheng Community Health Service Center， Dongguan 523165， China
- Publication Type:Journal Article
- Keywords:
metabolic associated fatty liver disease;
a body shape index;
body roundness index;
screening ability
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(6):854-863
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the screening ability of two new anthropometric indices： a body shape index （ABSI） and body roundness index （BRI） for metabolic associated fatty liver disease （MAFLD） in adults， and to determine the optimal cut-off value. MethodsBased on the valid baseline data collected from March 2018 to October 2019 in Dongguan City， Guangdong Province by South China Cohort （SCC） project， a total of 9 214 adults were included， with physical examination， ultrasound and laboratory tests. MAFLD was diagnosed according to the consensus statement of international experts. Body mass index （BMI）， waist circumference （WC） and waist-height-ratio （WHtR） were used as reference to evaluate the screening ability of ABSI and BRI. Spearman rank test and logistic regression model were used to compare the correlation between each index and MAFLD. The receiver operating characteristic curve （ROC） was used to compare the area under the curve （AUC）. ResultsThe prevalence of MAFLD was 31.41%， which increased linearly across the quartile of each index except ABSI. There was a positive correlation between each index and MAFLD but ABSI was the weakest （rs=0.069 in males and rs=0.045 in females） while BRI was stronger （rs=0.409 in males and rs=0.413 in females）. A multivariate logistic regression analysis of the presence of MAFLD for the highest quartile vs. the lowest quartile of each anthropometric measure， showed that ABSI had the lowest OR without statistical significance. The OR and 95%CI was 1.09 （0.85， 1.41） in males and 0.90 （0.74， 1.08） in females， respectively. BRI was similar to WHtR， and BMI had the strongest association whose OR and 95%CI was 61.15 （35.12， 106.47） in males and 20.07 （15.24， 26.43） in females， respectively. ABSI had the lowest AUC for MAFLD （0.55 in males and 0.53 in females） and the cut-off value was respectively 0.080 5 in males and 0.078 2 in females. BRI had a higher AUC （0.77 in males and 0.75 in females）， equal to WHtR and similar to WC （0.79 in males and 0.77 in females） but lower than BMI （0.81 in males and 0.79 in females）. The optimal cut-off value for BRI was 4.10 in males and 4.51 in females. BRI also showed a certain screening ability on MAFLD in lean/normal weight population （0.73 in males and 0.69 in females）， patients with diabetes （0.73 in males and 0.71 in females） and subjects with lean/normal weight and metabolic dysfunction （0.60 in males and 0.55 in females）. ConclusionsBRI can effectively identify MAFLD （AUC>0.7） and the optimal cut-off value is 4.10 for males and 4.51 for females， while ABSI performs poorly. Considering the screening on MAFLD in population with different characteristics， BRI shows a potential for use in early screening of MAFLD.
