Comparison of Efficiency of Paramagnetic Relaxation Enhancement of Gadolinium-Based Contrast Agents： a Phantom Study
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0603
- VernacularTitle:钆对比剂顺磁性弛豫增强效能比较的体模研究
- Author:
Yan-qing FENG
1
;
Ding-xiang XIE
1
;
Zhou-lei LI
1
;
Quan-fei MENG
1
;
Hong-zhang ZHU
1
Author Information
1. Department of Radiology， The First Affiliated Hospital， Sun Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
gadolinium-based contrast agents;
phantom;
magnetic resonance imaging;
signal intensity;
relaxometry
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(6):816-823
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the efficiency of paramagnetic relaxation enhancement of five gadolinium-based contrast agents （GBCAs） at the same dilution ratio and molar concentration.MethodsFive commonly used GBCAs， including 2 linear and 3 macrocyclic GBCAs， were employed and prepared to phantoms with the same molar concentration and dilution rate using distilled water. The phantoms were scanned in a 3.0 T MRI scanner under the same sequences and parameters. The regions of interest （ROIs） were drawn on the T1WI SE and T1 mapping images to quantitatively measure the T1WI signal intensity and T1 value from phantoms， calf muscles and surrounding air. The T1 relaxation rate （R1）， signal to noise ratio （SNR） and contrast noise ratio（CNR） were then calculated based on the T1WI signal intensity and T1 value. The relationship from signal intensity （Sp）， RSI， T1 value，R1， SNR， CNR and molar concentration were analyzed. The differences from Sp， RSI， T1 value， R1， SNR， CNR in 5 GBCAs were compared.ResultsIn the process of phantoms’s preparation， the total used dose of Gd-DO3A-butrol was lowest. Sp and RSI were curvilinearly correlated with the molar concentration of GBCAs（rs=0）. While T1p and SNR were negatively correlated with the molar concentration of GBCAs（rs<0）， R1 and CNR were positively correlated with the molar concentration of GBCAs. The Sp， T1 values， RSI， SNR and CNR from these five GBCAs were detected to be similar to each other， even between linear and macrocyclic GBCAs.ConclusionsUnder the same molar concentration， there are no significant difference of T1WI signal intensity and T1 value between linear and macrocyclic GBCAs phantoms found from Magnetic resonance imaging. What’s more， both high and low molar concentration of gadolinium-based contrast agents can decrease the T1WI signal intensity of phantom， but the T1 value will continue to decrease with the increase of the molar concentration.
