Exploration of ethical issues in preimplantation polygenic testing
10.12026/j.issn.1001-8565.2025.11.07
- VernacularTitle:植入前多基因检测的伦理问题探究
- Author:
Zehui YU
1
;
Lizhi LIANG
1
Author Information
1. School of Medical Humanities， Capital Medical University， Beijing 100069， China
- Publication Type:Journal Article
- Keywords:
preimplantation genetic testing;
polygenic risk score;
polygenic disease
- From:
Chinese Medical Ethics
2025;38(11):1425-1430
- CountryChina
- Language:Chinese
-
Abstract:
Preimplantation polygenic testing， as a frontier technology in assisted reproduction， provides a new way to prevent genetic diseases and reduce birth defects. However， it may also trigger a series of ethical issues. Combined with the research progress of preimplantation polygenic testing， this paper explored the ethical issues that may be caused by this technology， including the risks and uncertain benefits for future offspring and the challenges of informed consent， the dilemmas of autonomous decision-making and genetic responsibility of prospective parents， as well as social risks such as the distortion of the view of life and health inequities. Given the technical safety issues and ethical challenges posed by preimplantation polygenic testing， it was proposed to revise the regulations related to preimplantation genetic testing， as well as improve the ethical review of preimplantation polygenic testing， genetic counseling services， and public education on genetic science and genetic ethics. These ethical countermeasures aim to prevent and mitigate risks and ensure that technology truly benefits human society.
