Patterns and Mechanisms of Traditional Chinese Medicine in Treating Non-small Cell Lung Cancer Based on Theory of ''Supporting Healthy Qi and Eliminating Pathogens''
10.13422/j.cnki.syfjx.20250624
- VernacularTitle:基于“扶正祛邪”理论探讨中医药治疗非小细胞肺癌的规律及机制
- Author:
Pengfei ZHANG
1
;
Huijuan ZHANG
1
;
Jianqing LIANG
1
;
Jinhua WANG
1
Author Information
1. School of Basic Medicine， Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
non-small cell lung cancer;
clinical syndromes;
drug selection;
medication patterns;
pharmacological mechanisms
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(24):228-237
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer （NSCLC）， as the most common subtype of lung cancer， has a high incidence and mortality rate among global cancer cases. Although modern medicine has made remarkable progress in the treatment of NSCLC with advances in screening technologies and continuous optimization of therapeutic regimens， current treatments inevitably result in adverse outcomes such as high tumor recurrence rates， significant toxic side effects， and poor quality of life for patients. Traditional Chinese medicine （TCM） holds that the core pathogenesis of lung cancer lies in ''deficiency of healthy Qi and excess of pathogenic factors''. It originates from congenital insufficiency or acquired malnourishment， leading to an imbalance of Yin and Yang， deficiency of healthy Qi， and inability to eliminate pathogenic factors. The interactions among Qi stagnation， phlegm accumulation， blood stasis， and toxins give rise to disease. The root is deficiency， while the manifestation is excess. Therefore， the treatment of lung cancer in TCM is generally guided by the principle of "supporting the healthy Qi and eliminating the pathogens". A large number of clinical and pharmacological studies have shown that TCM and its active components can， through multiple targets and mechanisms， alleviate postoperative and chemoradiotherapy-related adverse reactions， inhibit tumor growth and recurrence， and improve the quality of life of patients with NSCLC. It is worth noting that although extensive studies have been conducted on the therapeutic patterns and pharmacological mechanisms of TCM and its active substances in NSCLC treatment， issues such as the diversity of medicinal materials， the complexity of chemical components， the scientific basis of herbal compatibility， and the flexibility of dosage indicate that there is still considerable room for further clinical and basic research. This review summarizes recent literature on the clinical syndromes， drug selection， medication patterns， and pharmacological mechanisms of TCM and its active components in the treatment of NSCLC， aiming to provide guidance for clinical medication in TCM therapy for NSCLC and to deepen the understanding and research of its therapeutic mechanisms.
