Research progress on the role of extracellular histones in xenotransplantation
10.12464/j.issn.1674-7445.2025199
- VernacularTitle:细胞外组蛋白在异种移植中的作用研究进展
- Author:
Kun WANG
1
;
Yu ZHANG
1
;
Yuxiang CHEN
1
;
Xiaojie MA
2
;
Tao LI
1
;
Hongtao JIANG
1
Author Information
1. Department of Renal Transplantation, the Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China.
2. .
- Publication Type:ReviewArticle
- Keywords:
Extracellular histone;
Xenotransplantation;
Organ transplantation;
Rejection;
Immune cell;
Damage-associated molecular pattern;
Neutrophil extracellular trap;
NOD-like receptor protein 3
- From:
Organ Transplantation
2025;16(6):962-969
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation faces the challenge of a shortage of donors. Although xenotransplantation holds great potential, it is limited by rejection. Extracellular histones, as key members of damage-associated molecular patterns, have been proven in recent years to play a crucial role in transplant rejection by activating innate immunity, regulating the coagulation-inflammation network, and modulating adaptive immune responses. However, the specific functions and key mechanisms remain to be clarified. Therefore, this article reviews the structural characteristics of histones, their release pathways, the biological functions of extracellular histones, and their potential roles in xenotransplantation. It summarizes the latest research progress of extracellular histones in xenotransplantation, analyzes the shortcomings of existing research and the direction for future research, with the expectation of providing references for the application of extracellular histones in xenogeneic kidney transplantation.
