Correlation between Helicobacter pylori infection and gastrointestinal hormone levels in elderly patients with chronic atrophic gastritis
10.3969/j.issn.1006-2483.2025.06.025
- VernacularTitle:老年慢性萎缩性胃炎患者幽门螺杆菌感染及胃肠激素的相关性分析
- Author:
Fang HU
1
;
Ru ZHANG
1
Author Information
1. Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China
- Publication Type:Journal Article
- Keywords:
Chronic atrophic gastritis;
Helicobacter pylori infection;
Gastrointestinal hormones
- From:
Journal of Public Health and Preventive Medicine
2025;36(6):109-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between Helicobacter pylori infection and gastrointestinal hormone levels in elderly patients with chronic atrophic gastritis (CAG), and to provide a theoretical basis for clinical treatment. Methods From January 2024 to December 2024, 3000 elderly CAG patients with Helicobacter pylori infection admitted to four tertiary hospitals in Xi’ an City were selected as the study group, and 3000 elderly CAG patients without Helicobacter pylori infection were enrolled as the control group according to the ratio of 1:1. The risk factors of Helicobacter pylori infection in elderly patients with CAG were explored by logistic multivariate regression analysis, and the association between Helicobacter pylori infection and gastrointestinal hormones in elderly CAG patients was analyzed. Results There were statistically significant differences in smoking history, alcohol drinking history, overeating, spicy diet, bile reflux, abuse of antibiotics, and levels of vasoactive intestinal peptide (VIP), gastrin (GAS), cholecystokinin (CCK), and motilin (MTL) between the two groups (P<0.05). Logistic multivariate analysis indicated that smoking history, alcohol drinking history, overeating, spicy diet, bile reflux, and abuse of antibiotics were independent risk factors of Helicobacter pylori infection in elderly patients with CAG, and VIP, GAS, CCK and MTL levels were associated with Helicobacter pylori infection in elderly CAG patients (P<0.05). Conclusion Helicobacter pylori infection in elderly patients with CAG is closely associated with gastrointestinal hormone levels. It is necessary to take active prevention and treatment measures for this population in clinical practice.
