Visceral adipose tissue and four gastrointestinal disorders: a two-sample Mendelian randomization study
10.3969/j.issn.1006-2483.2025.06.004
- VernacularTitle:内脏脂肪组织与四种消化系统疾病：两样本孟德尔随机化和荟萃分析研究
- Author:
Liyuan FANG
1
;
Yuhang FANG
2
;
Runxi WANG
1
;
Ying ZHANG
1
Author Information
1. Guang'anmen Hospital , China Academy of Chinese Medical Sciences, Beijing 100053 , China
2. Beijing University of Chinese Medicine, Beijing 100029, China
- Publication Type:Journal Article
- Keywords:
Visceral adipose tissue;
Peptic ulcer disease;
Irritable bowel syndrome;
Mendelian randomization
- From:
Journal of Public Health and Preventive Medicine
2025;36(6):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential causality between visceral adipose tissue (VAT) and inflammatory bowel disease, peptic ulcer disease, irritable bowel syndrome and gastroesophageal reflux disease. Methods Two-sample Mendelian randomization (MR) investigations were carried out, employing genetic variants closely linked with VAT as instrumental variables. The summary data for aforementioned gastrointestinal disorders were obtained from the genome-wide association study (GWAS) in UK biobank and Finn Gen databases, respectively. The inverse variance-weighted method (IVW) was employed as the primary analytical method, bolstered by a sequence of sensitivity analyses to verify the robustness of MR. Subsequently, a meta-analysis was conducted to amalgamate the findings derived from both databases. Results This study included a total of 42 single nucleotide polymorphisms that were strongly associated with visceral adipose tissue as instrumental variables. Statistically significant correlations were found between VAT and peptic ulcer (OR=1.17, 95% CI: 1.08-1.27, P < 0.01), gastroesophageal reflux disease (OR=1.10, 95% CI: 1.03-1.18, P = 0.02), and irritable bowel syndrome (OR=1.12, 95% CI: 1.04-1.12, P = 0.03). There was no statistical significance between VAT and inflammatory bowel disease (OR=0.94, 95% CI: 0.79-1.12, P = 0.65). Conclusion VAT exhibits a causal linkage with peptic ulcer, gastroesophageal reflux disease, and irritable bowel syndrome. Accurately assessing VAT levels via imaging methods, screening individuals at high-risk, and actively controlling abdominal obesity bear important clinical significance.
