Comparative Analysis of Efficacy and Safety of Surgery and Drugs in the Treatment of Epilepsy Caused by Cerebral Cavernous Vascular Malformation
- VernacularTitle:对比手术与药物治疗脑海绵状血管畸形所致癫痫的疗效与安全性分析
- Author:
Yu-wei XU
1
;
Zi-yi CHEN
2
;
Yan-zhen ZHU
2
;
Rong MO
2
;
Xian-jie ZENG
1
Author Information
1. Department of Neurology，Chaozhou Peoples Hospital，Chaozhou 521000，China
2. Department of Neurology，National Key Clinical Department and Key Discipline of Neurology，The First Affiliated Hospital， Sun Yat-sen University，Guangzhou 510080，China
- Publication Type:Journal Article
- Keywords:
cerebral cavernous malformations;
epilepsy;
drug therapy;
surgical treatment
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(2):266-270
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the efficacy， safety and influencing factors of different treatment methods for epilepsy caused by cerebral cavernous malformations. MethodsWe retrospectively enrolled 71 patients with cerebral cavernous malformation with epilepsy as the main manifestation， who were divided into a drug-only group of 42 patients and a surgery combined with drug therapy group （surgery group） of 29 patients. The effects of both treatments were analyzed. ResultsComparison of the efficacy between the drug group and the surgery group showed that 32（76.2%） were effective in the former while 22（75.9%） were effective in the latter； there was no statistical difference between the two groups （P>0.05） However， a subgroup analysis of the number of lesions found that among patients with multiple lesions， 3 （75.0%） were effective in the drug group， as compared with 0 （0%） in the surgical group， and the effective rate of the drug group was higher than that of the surgical group. Among patients with a single lesion， the effective rate was higher in the surgical group than that in drug group with statistical significance ［22（95.7%） vs. 28（73.7%）， P<0.05］. There was no significant difference between the severity of EEG and the treatment effect （P>0.05）. ConclusionsEffectiveness of Drug therapy and surgical treatment of spongiform plasma malformations caused by epilepsy was similar， but surgical treatment may have postoperative complications and affect the prognosis. Patients with epilepsy caused by a single cavernous vascular malformation are recommended to be treated with surgery， while patients with epilepsy caused by multiple cavernous vascular malformations should be treated with caution.
