Research progress on the pathogenesis of airway mucus hypersecretion in bronchial asthma and the intervention of traditional Chinese medicine
- VernacularTitle:支气管哮喘气道黏液高分泌的发病机制及中药干预研究进展
- Author:
Ruiyi CHEN
1
;
Liu CHUN
2
;
Weike LI
1
;
Ju YANG
1
;
Zhiwan WANG
3
Author Information
1. National Regional Center for Traditional Chinese Medicine （Pulmonary Disease） Diagnosis and Treatment，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450003，China
2. National Regional Center for Traditional Chinese Medicine （Pulmonary Disease） Diagnosis and Treatment，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;Henan Collaborative Innovation Center for Diagnosis，Treatment and New Drug Development of Respiratory Diseases，Zhengzhou 450003，China;Henan Key Lab of Chinese Medicine for Respiratory Disease，Zhengzhou 450003，China
3. National Regional Center for Traditional Chinese Medicine （Pulmonary Disease） Diagnosis and Treatment，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;Henan Collaborative Innovation Center for Diagnosis，Treatment and New Drug Development of Respiratory Diseases，Zhengzhou 450003，China
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
airway mucus hypersecretion;
traditional Chinese medicine;
pathogenesis;
research progress
- From:
China Pharmacy
2025;36(22):2862-2867
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma （abbreviated as asthma） is one of the common chronic airway inflammatory diseases in the respiratory system， which is difficult to cure. Airway mucus hypersecretion （AMH） is an important factor leading to acute asthma attacks. Traditional Chinese medicine （TCM） possesses therapeutic advantages characterized by multiple pathways， multiple targets， and multiple links， and its mechanism of action in intervening in AMH has gradually drawn attention. TCM can effectively alleviate the symptoms of patients by intervening in asthma through methods such as eliminating phlegm and eliminating fluid retention. This review finds that the pathogenesis of asthma-associated AMH is correlated with decreased mucociliary clearance function and enhanced mucus secretion function； single TCM （such as Platycodon grandiflorum）， effective components of TCM （such as pinellia polysaccharides）， and compound prescriptions （mainly heat-clearing and phlegm-resolving prescriptions， etc.） can improve asthma-associated AMH by regulating the PI3K/Akt and JAK/STAT signaling pathways， inhibiting airway inflammatory responses， oxidative stress， and recovering the water-salt ratio of the mucus layer itself.
