The role and mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of radiation-induced skin injury
10.13491/j.issn.1004-714X.2025.05.024
- VernacularTitle:脂肪间充质干细胞外泌体在放射性皮肤损伤治疗中的作用及机制
- Author:
Rong ZHANG
1
;
Yongtao SU
2
Author Information
1. Institute of Tissue Regeneration and Wound Repair, Shandong University of Traditional Chinese Medicine, Jinan 250355 , China;Zibo First Hospital, Zibo 255000 , China.
2. Institute of Tissue Regeneration and Wound Repair, Shandong University of Traditional Chinese Medicine, Jinan 250355 , China.
- Publication Type:ReviewArticles
- Keywords:
Adipose-derived mesenchymal stem cell;
Exosome;
Radiation-induced skin injury
- From:
Chinese Journal of Radiological Health
2025;34(5):776-782
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced skin injury is one of the common adverse reactions of radiotherapy, involving skin, blood vessels, glands, and bones, and may even lead to carcinogenesis. It is characterized by high incidence, long treatment process, and high cost. In recent years, adipose-derived mesenchymal stem cells and their secreted exosomes have become a research hotspot in tissue repair. Exosomes can secrete a variety of cytokines related to wound repair and exhibit various biological functions, including inhibition of oxidative stress, modulation of inflammation, regulation of DNA damage repair, promotion of cell proliferation and migration, reduction of fibrosis, and regulation of the extracellular matrix. Exosomes are currently a major source of cytokines in the field of tissue repair and regeneration. This article reviews the application and therapeutic prospects of adipose-derived mesenchymal stem cell exosomes in radiation-induced skin injury, aiming to provide new ideas for the clinical treatment of this condition.
