Effects of whole breast combined with regional nodal hypofractionated radiotherapy on PLC and NLR in patients with breast cancer
10.13491/j.issn.1004-714X.2025.05.010
- VernacularTitle:乳腺癌全乳联合区域淋巴结大分割放疗对PLC和NLR的影响
- Author:
Yang ZHOU
1
;
Xiaohong WANG
2
;
Bin LI
2
;
Yuwei WANG
3
;
Jiangong WANG
3
;
Yufeng LI
4
Author Information
1. Hebei Key Laboratory of Molecular Oncology, The Cancer Institute, Tangshan 063001, China;The Sixth Department of Chemoradiotherapy, Tangshan People's Hospital, Tangshan 063001, China.
2. The Sixth Department of Chemoradiotherapy, Tangshan People's Hospital, Tangshan 063001, China.
3. The Eighth Department of Chemoradiotherapy, Tangshan People's Hospital, Tangshan 063001, China.
4. Hebei Key Laboratory of Molecular Oncology, The Cancer Institute, Tangshan 063001, China.
- Publication Type:OriginalArticles
- Keywords:
Breast cancer;
Whole breast combined with regional nodal irradiation;
Hypofractionated radiotherapy;
Conventional fractionated radiotherapy;
Peripheral lymphocyte count;
Neutrophil-to-lymphocyte ratio
- From:
Chinese Journal of Radiological Health
2025;34(5):679-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of whole breast combined with regional nodal hypofractionated radiotherapy compared with conventional fractionated radiotherapy on peripheral lymphocyte count (PLC) and neutrophil-to-lymphocyte ratio (NLR) in patients with breast cancer after breast-conserving surgery. Methods This retrospective study enrolled 94 patients with breast cancer who underwent breast-conserving surgery in Tangshan People’s Hospital between April 2022 and April 2024. All patients received whole breast combined with regional nodal radiotherapy. These patients were divided into hypofractionated radiotherapy group (n = 42) and conventional fractionated radiotherapy group (n = 52) according to radiotherapy regimen. Differences in PLC and NLR before and after radiotherapy between the two groups were compared using the t-test. Results Before radiotherapy, the baseline PLC and NLR were comparable between the two groups (P > 0.05). After radiotherapy, PLC decreased and NLR increased in both groups (P < 0.05). The PLC in the hypofractionated radiotherapy group was significantly higher than that in the conventional fractionated radiotherapy group (0.95 ± 0.30 vs. 0.77 ± 0.26, P = 0.002), and the NLR was significantly lower in the hypofractionated radiotherapy group than in the conventional fractionated radiotherapy group (2.86 ± 1.27 vs. 3.67 ± 1.59, P = 0.010). Conclusion Compared with conventional fractionated radiotherapy, whole breast combined with regional nodal hypofractionated radiotherapy has less impact on PLC and NLR in patients with breast cancer after breast-conserving surgery.
