The role of serum HBV RNA in the clinical management of chronic HBV infection
- Author:
WANG Aili
;
LI Jing
;
BAO Zihong
- Publication Type:Review
- Keywords:
hepatitis B virus;
chronic hepatitis B virus infection;
hepatitis B virus RNA;
covalently closed circular DNA
- From:
China Tropical Medicine
2025;25(3):304-
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B virus (HBV) infection remains a major global public health concern. The persistent presence of intrahepatic covalently closed circular DNA (cccDNA) poses a major challenge to the complete cure of chronic HBV infection. Therefore, identifying reliable and effective serological surrogate markers for cccDNA holds great clinical significance in evaluating antiviral efficacy, predicting prognosis, and guiding the clinical management of chronic HBV-infected patients. In recent years, serum HBV RNA has emerged as a promising non-invasive alternative marker for cccDNA, offering the potential for monitoring disease progression and predicting prognosis in chronic HBV-infected patients. In this review, we summarize recent studies on HBV RNA, highlighting its ability to assess the immune and histological status of patients, and discussing its value in guiding the timing of antiviral therapy. Furthermore, we systematically summarize the clinical significance of HBV RNA in multiple domains: monitoring viral replication, evaluating antiviral treatment efficacy, predicting relapse after treatment cessation, and guiding new antiviral strategies. This review aims to provide clinicians with valuable insights for better utilizing this marker in the clinical management of chronic HBV infection.
- Full text:20251117171603467718.The role of serum HBV RNA in the clinical management of chronic HBV infection.pdf
