Association between serum ferritin levels and hepatic steatosis in patients with hepatitis c virus infection
- VernacularTitle:Гепатит с вирусийн халдварын үед цусны ферритинийг элэгний өөхжилттэй уялдуулан судалсан дүн
- Author:
Urtnasan Ts
1
;
Oyunchimeg D
2
;
Batbold B
3
Author Information
1. Educational Policy and Management, Etugen University
2. Department of Bio-medician, School of Health, Etugen University,
3. Institute of Medical Sciences
- Publication Type:Journal Article
- From:
Diagnosis
2025;113(2):74-80
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:According to the World Health Organization (WHO), by 2030, the number of deaths from cancer worldwide is estimated to reach 13.2 million. However, this number is expected to increase to 20.3 million due to population growth. As of 2018, liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide. Hepatitis C virus (HCV) is one of the main causes of chronic liver disease, cirrhosis, and liver cancer.
HCV is estimated to infect 175 million people globally, accounting for 2.8–3% of the total population. About 20% of people infected with HCV progress to severe liver disease, sometimes requiring liver transplantation.
In our country, the prevalence of chronic hepatitis increased significantly between 2015 and 2019. In 2019, it accounted for 45.3% of the total liver diseases, an increase of 10.3 percentage points since 2015. When analyzing age groups, it is noteworthy that incidence increased by 3.2 times in children aged 0-9 years.
Objectives of the study:To determine the level of ferritin in the blood of patients with hepatitis C virus infection and to assess its relationship with fatty liver.
Research materials and methods:This study was conducted using a cross- sectional design. The data were collected before the initiation of anti-HCV treatment, and each participant underwent serum biochemical analysis to assess basic iron metabolism indicators such as ferritin and transferrin.
Conclusion:Of the 115 participants in the study, 27% (31) had elevated ferritin levels, while 73% (84) had normal levels. The mean ferritin level was 336±262 ng/ mL, indicating that a significant number of participants had elevated ferritin levels. This suggests that ferritin levels are increased in cases of liver cell inflammation and injury. Although biopsy-proven fatty liver disease was not present, 97.4% (112) of the participants had elevated blood lipid levels, and 94.6% of these had elevated ferritin levels. However, the chi-square test did not reveal a statistically significant difference (χ² = 0.170, p = 0.681). Additionally, 91.5% of participants with high HDL also had elevated ferritin, but the relationship was not statistically significant (p = 0.117).
- Full text:2025111416245637862Diagnosis-2025-113(2)-74-80.pdf
