A study on vancomycin-associated renal function impairment
- VernacularTitle:Ванкомицины шалтгаант бөөрний үйл ажиллагааны алдагдлыг судлах нь
- Author:
Kherlen G
1
;
Tamiraa Ts
1
;
Khaliun N
2
Author Information
1. School of Health Science, Etugen Medical University
2. Pharmacology Department, School of Bio-Medicine, MNUMS
- Publication Type:Journal Article
- From:
Diagnosis
2025;113(2):21-28
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Vancomycin is a glycopeptide antibiotic widely used to treat infections caused by gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA). Despite its effectiveness, vancomycin is known to be nephrotoxic, particularly when administered in high doses, for prolonged durations, or in combination with other nephrotoxic agents. This study aims to investigate the incidence and influencing factors of vancomycin associated renal impairment among hospitalized patients in Mongolia.
Methods:A retrospective document review was conducted among 120 hospitalized patients who received vancomycin at the First State Central Hospital in 2023. Data on vancomycin dosage, treatment duration, clinical diagnoses, and biochemical parameters were analyzed. Renal function was assessed using the Cockcroft-Gault equation and categorized into five stages. Statistical analysis was performed using chi-square tests and logistic regression with a significance level set at p<0.05.
Results:The mean age was 52.3 years, and the average BMI was 26.7. Among participants, 41.5% showed varying degrees of renal impairment. Vancomycin daily dose was significantly associated with the stage of renal impairment (p=0.040), while total dose and treatment duration were not. Co-administration with cefotaxime and metronidazole showed statistically significant changes in creatinine and urea levels, suggesting potential additive nephrotoxicity.
Conclusion:The findings indicate a substantial rate of renal function decline among vancomycin-treated patients. Higher daily doses and concurrent use of nephrotoxic antibiotics may increase the risk. Regular renal monitoring and dose adjustments are essential to minimize adverse renal outcomes.
- Full text:2025111415415151554Diagnosis-2025-113(2)-21-28.pdf
