To study vancomycin-induced white blood cell changes and factors influencing them
- VernacularTitle:Ванкомицины шалтгаант цагаан эсийн өөрчлөлтүүд болон түүнд нөлөөлөх хүчин зүйлийг судлах нь
- Author:
Tsetsegdulam B
1
;
Tamiraa Ts
2
;
Khaliun N
3
Author Information
1. School of Pharmacology, Etugen Medical University
2. School of Health Science, Etugen Medical University
3. Pharmacology Department, School of Bio-Medicine, MNUMS
- Publication Type:Journal Article
- From:
Diagnosis
2025;113(2):11-20
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Vancomycin was first approved by the US Food and Drug Administration (FDA) in 1958. Vancomycin has an active effect on gram-positive microorganisms, such as methicillin- resistant Staphylococcus aureus (MRSA), coagulase-negative staphylococcus, Streptococcus (Enterococcus faecalis), and Clostridia (Clostridium difficile). It is used in the treatment of severe infections such as endocarditis, osteomyelitis, pneumonia, blood and soft tissue infections, other staphylococcal infections, and S. epidermidis with a β-lactam ring structure that is ineffective or allergic to antibiotics and resistant to many drugs. Materials and Methods: To carry out the study, we obtained permission to conduct the study from the National Institute of Health and Welfare, and randomly sampled a total of 274 inpatients who used vancomycin in the hospital in 2023 in order to be representative in terms of age and gender (n=120).
Results:The one dose of vancomycin was 0.9 mg, the daily dose was 2.4 mg, the total dose was 20.5 mg, and the total daily average was 11.3 days. The daily dose and total dose of vancomycin were inversely proportional to age (r=-0.008), and the total dose is very weakly correlated with BMI and gender (r=0.052). Cefazolin used in combination with vancomycin had statistically significant differences in monocyte counts (p=0.003), cefotaxime in lymphocyte counts (p=0.027), and ceftriaxone in total white blood cell counts (p=0.048). Conclusion: Vancomycin daily dose is inversely related to age, total dose is inversely related to age, and total dose is very weakly correlated with BMI and gender. There is a statistically significant difference in the use of vancomycin with cephalosporin antibiotics
- Full text:2025111415370115273Diagnosis-2025-113(2)-11-20.pdf
