Clinical characteristics and treatment measures of 114 elderly patients with severe dengue in Guangdong Province
- Author:
WANG Changtai
;
YANG Huiqin
;
HONG Wenxin
- Publication Type:Journal Article
- Keywords:
Dengue fever;
severe dengue;
clinical characteristics;
treatment;
elderly;
Guangdong
- From:
China Tropical Medicine
2024;24(12):1534-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and treatment measures of elderly patients with severe dengue (SD) in Guangdong Province, providing a scientific basis for the clinical treatment of elderly SD patients. Methods Clinical data of elderly patients with SD hospitalized in four cities in Guangdong Province from January 2014 to December 2023 were collected. The clinical characteristics of elderly patients between the younger elderly (<80 years old) and the older elderly (≥80 years) were compared, and different treatment measures and clinical outcomes were statistically analyzed. Results Among the 114 elderly SD patients, 34.21% were the older elderly, and 81.58% had underlying diseases, including hypertension (64.04%), chronic heart disease (42.98%), cerebrovascular disease (28.07%), and diabetes (21.05%). Among elderly SD patients, 42.11% had normal or elevated white blood cell counts, 81.58% had a platelet count of <50×109/L and 52.63% had albumin levels <30 g/L. There was no statistically significant difference in symptoms, signs, and laboratory indicators between the younger elderly and the older elderly (P>0.05). The incidence rates of severe plasma leakage, severe bleeding, and severe organ damage in severe manifestation were 29.82%, 34.21%, and 63.16% respectively, with no statistically significant difference between the younger elderly and the older elderly (P>0.05). All patients were treated with intravenous infusion, organ support, nutritional support, and other treatments upon admission, with the usage rates of human serum albumin, platelets, red blood cells, glucocorticoids, intravenous immunoglobulin, antibiotics, and antifungal drugs being 60.53%, 55.26%, 19.30%, 35.96%, 30.70%, and 78.95% respectively. Mechanical ventilation and renal replacement therapy were administered to 22.81% and 8.77% of patients. Finally, 32.46% of patients were admitted to the intensive care unit, and 16.67% died. Conclusions Elderly patients with SD often have underlying diseases and severe organ damage is more common, with a high mortality rate. The clinical characteristics of the younger elderly and older elderly patients are similar. In clinical practice, early identification of severe cases and developing individualized comprehensive treatment measures based on underlying diseases and clinical characteristics are key to treating elderly patients with SD.
- Full text:202511131530181697817.Clinical characteristics and treatment measures of 114 elderly patients with severe dengue in Guangdong Province.pdf
