Mechanism of active ingredients and compound formula of traditional Chinese medicine intervening in sepsis-associated acute kidney injury via the NF-κB signaling pathway
- VernacularTitle:中药活性成分及复方通过NF-κB通路干预脓毒症相关性急性肾损伤的作用机制
- Author:
Min XIANG
1
;
Siyuan CHEN
1
Author Information
1. Dept. of Critical Care Medicine，West China Hospital，Sichuan University，Chengdu 610041，China
- Publication Type:Journal Article
- Keywords:
sepsis;
acute kidney injury;
nuclear factor-κB;
traditional Chinese medicine;
active ingredients;
compound formula
- From:
China Pharmacy
2025;36(21):2747-2752
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-associated acute kidney injury （SA-AKI） is an acute kidney injury caused by sepsis， characterized by acute onset， severe progression and high mortality. The abnormal activation of the nuclear factor-κB （NF-κB） signaling pathway can lead to pathological processes such as renal inflammatory cascade reactions， oxidative stress， apoptosis and pyroptosis， and microcirculatory dysfunction， thereby promoting the development of SA-AKI. In recent years， the basic research on the prevention and treatment of SA-AKI with traditional Chinese medicine （TCM） has made significant progress， among which NF-κB plays an important role as a key factor. This article summarizes the research findings over the past few years on active ingredients and compound formula of TCM interventions for SA-AKI via the NF-κB signaling pathway. It elaborates on various active ingredients of TCM， such as flavonoids， phenols， glycosides， terpenoids， quinones and alkaloids， as well as TCM compound formulations including Qihuang jiedu huayu decoction， Huangqi jiuni decoction， and Xuebijing injection， etc. These interventions significantly inhibit renal inflammatory responses， oxidative stress， apoptosis， pyroptosis and microcirculatory dysfunction by regulating multiple NF-κB-mediated signaling pathways， such as Toll-like receptor 4/myeloid differentiation primary response protein 88/NF- κB， sirtuin 1/NF- κB， NF- κB/NOD-like receptor family pyrin domain-containing protein 3， thereby alleviating SA-AKI and improving renal function.
