Research progress in analytical technologies for characterizing pharmacodynamic substance basis of traditional Chinese medicine compound prescriptions
- VernacularTitle:中药复方药效物质基础分析技术研究进展
- Author:
Yuan YUAN
1
;
Di NIU
1
;
Xinxin PANG
2
;
Chaoyang DU
1
;
Yanan WANG
1
;
Ruifang CHEN
1
Author Information
1. The Second Clinical Medical School，Henan University of Chinese Medicine，Zhengzhou 450011，China
2. Dept. of Nephrology，Henan Provincial Hospital of Traditional Chinese Medicine/the Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine compound prescriptions;
pharmacodynamic substance;
analytical technology
- From:
China Pharmacy
2025;36(21):2738-2741
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine （TCM） compound prescriptions serve as crucial practical embodiments of TCM theoretical frameworks， characterized by their complex multi-component composition and multi-target interactions. The research on the material basis of their pharmacological effects has gradually become the key to promoting the modernization of TCM. In recent years， new ideas and theories regarding the research on pharmacodynamic substance basis of TCM compound prescriptions have been continuously proposed. This review systematically summarizes and reviews analytical techniques such as targeted fishing technology， spectrum-effect relationship analysis， serum pharmacochemistry， network pharmacology， high-throughput screening， and cell membrane chromatography. It is found that these techniques exhibit unique advantages in areas including target-specific analysis， component-pharmacological effect correlation analysis， identification of the material basis in vitro and in vivo， prediction of multi-target mechanisms， efficient screening of active ingredients， and analysis of interactions between cell membrane receptors. These techniques compensate for the shortcomings of traditional research methods， enhance the systematicness and precision of research on pharmacodynamic substance based TCM compound prescriptions， and can provide theoretical support for the promotion and clinical application of TCM compound prescriptions.
