Analysis of clinical features of 10 cases of acute Q fever
- Author:
ZHAO Hua
;
ZHANG Bin
;
ZHANG Xian
- Publication Type:Case Reports
- Keywords:
Q fever;
Coxiella burnetii;
clinical features;
mNGS
- From:
China Tropical Medicine
2024;24(11):1424-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of acute Q fever to improve the understanding of the disease. Methods The clinical data of 10 patients with acute Q fever admitted to the Affiliated Hospital of Nantong University from November 2020 to December 2023 were collected, and the general data, epidemiological characteristics, clinical manifestations, laboratory test results, imaging manifestations, treatment plans, and outcomes were retrospectively analyzed. Results Among the 10 patients, there were 7 males and 3 females, with an average age of (58.30±6.41) years. Three patients had contact history with sheep, one with poultry, and six without clear epidemiological history. The main clinical manifestations were fever, chills, fatigue, cough, headache, nausea, etc. Laboratory tests showed slight leukocytosis in one case, leukopenia in two cases, elevated neutrophil ratio in three cases, and lymphopenia in two cases; procalcitonin was elevated in six cases; C-reactive protein, D-dimer, alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase were elevated in all cases; Coxiella burnetii was detected in all 10 patients by metagenomic next-generation sequencing (mNGS). Upon diagnosis, treatment regimens were adjusted for all patients, using doxycycline or minocycline either alone or in combination, and all patients recovered and were discharged from the hospital. Conclusions Acute Q fever patients often have no clear epidemiological history and lack characteristic clinical manifestations, making conventional laboratory tests insufficient for diagnosis. mNGS examination can provide a basis for etiological diagnosis of suspected cases, and comprehensive treatment based on doxycycline or minocycline shows good efficacy.
- Full text:20251112103014120021.Analysis of clinical features of 10 cases of acute Q fever.pdf
