A case analysis of a rare HIV patient with integrase strand transfer inhibitor resistance
- Author:
LI Ting
;
LI Jungang
;
LI Mei
- Publication Type:Case Reports
- Keywords:
AIDS;
integrase;
drug resistance testing;
antiviral therapy
- From:
China Tropical Medicine
2024;24(10):1290-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations, diagnosis, treatment, and prognosis of an AIDS patient resistant to integrase inhibitors (INSTIs) to integrase strand transfer inhibitors (INSTIs), and to analyze the causes of drug resistance and preventive approaches. Methods A case of an AIDS patient resistant to both first- and second-generation INSTIs was reported, with an analysis of the causes of resistance based on the case. Results In this case, the initial drug resistance test for this patient indicated no mutation sites in the protease region, with some mutation sites in nucleotide reverse transcriptase and non-nucleotide reverse transcriptase. After changing the treatment plan to one containing INSTIs, the antiviral treatment still failed, and then the re-drug resistance test found that the patient was resistant to INSTIs, then after adjusting the regimen, the antiviral treatment was successful. The late diagnosis of this patient, the discontinuation of medication during treatment, and the fact that the testing for resistance to INSTIs was not included in routine resistance testing at that time contributed to the patient's significant resistance to INSTIs. The Q148R mutation in the integrase region played a key role in INSTIs resistance in this case. Conclusions AIDS patients should be strengthened with awareness-raising, nursing care, and follow-up to increase the patient's adherence to medication. Nowadays, with the increasing use of integrase inhibitors, it is recommended to include INSTI resistance testing in routine resistance tests to fully grasp the drug resistance of patients, reduce the occurrence of drug resistance, and improve the survival rate and quality of life of patients.
- Full text:202511120953596166023.A case analysis of a rare HIV patient with integrase strand transfer inhibitor resistance.pdf
