Progress on animal models of maxillary expansion and its application effect
10.12016/j.issn.2096-1456.202440464
- Author:
CAO Xinyue
1
;
XIAO Liwei
1
Author Information
1. Center of Stomatology, The Second Xiangya Hospital of Central South University
- Publication Type:Review
- Keywords:
stomatology；orthodontic；malocclusion；maxillary transverse deficiency；maxillary expansion；animal model；orthodontic appliances；application prospect
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(11):1010-1018
- CountryChina
- Language:Chinese
-
Abstract:
Maxillary expansion serves as the principal treatment for maxillary transverse deficiency in clinical practice. Simulating maxillary expansion in animals is the main research approach to assess its mechanism, effect, and stability. Thus, the animal model of maxillary expansion holds great significance in orthodontic research. Rats and rabbits are typically selected for common animal models because the maintenance cost is relatively low; however, their oral anatomy and masticatory behaviors differ significantly from those of humans, and their bone metabolism rates are substantially higher. Consequently, these factors should be carefully considered when extrapolating research findings and applying them to human clinical applications. Miniature pigs and dogs exhibit maxillofacial structures and chewing patterns that closely resemble those of humans; however, their broader application in research is constrained by high maintenance costs and ethical concerns. Rats with small oral space typically require the use of an elastic stainless steel wire expansion appliance, which can be divided into anterior maxillary expansion and posterior maxillary expansion. Rabbits, miniature pigs, and dogs have sufficient oral space and can be fitted with a variety of expansion appliances, including traditional tooth-borne expansion, microimplant-assisted expansion, and new magnetic expansion appliance. Animal models of maxillary expansion are currently used to study the mechanism of mechanically induced bone remodeling in order to provide potential therapeutic targets to promote bone remodeling in clinical orthodontic treatment; different orthodontic devices have been compared and evaluated to verify the correction effect of a new type of orthodontic device and provide experimental evidence for its clinical application; and supplementary methods of maxillary expansion have been screened to explore drug and physical therapy to accelerate the osteogenesis of the palatal suture, so as to shorten the retention time of clinical maxillary expansion and provide patients with more efficient and comfortable treatment. This paper summerized advances in animal models of maxillary expansion and the application effects in order to provide a reference for using an animal model of maxillary expansion.
- Full text:2025111110314854135上颌扩弓动物模型及应用效果的研究进展.pdf
