The role of circadian rhythm and its new strategies for prevention and treatment in oral diseases
10.12016/j.issn.2096-1456.202440495
- Author:
WANG Yajun
1
;
ZHANG Lin
2
;
CHENG Chen
1
;
XING Wenmin
1
;
GE Xuejun
1
;
CHENG Fengli
3
;
ZHANG Fang
1
Author Information
1. Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Clinical Medical Research Center of Oral Diseases of Shanxi Province
2. Academy of Medical Sciences, Shanxi Medical University
3. The Second Hospital of Shanxi Medical University
- Publication Type:Review
- Keywords:
circadian rhythm genes;
oral diseases;
sleep disorder;
psychoneuroimmunology;
oxidative stress;
oral microbiota;
sleep management
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(11):986-996
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythm is a biological endogenous process regulated by the suprachiasmatic nucleus of the hypothalamus, which transmits light signals to peripheral clocks and synchronizes the body with the external environment through balanced expression of circadian rhythm genes. Working the night shift, sleep disorders, and exposure to artificial light can lead to disturbances in circadian rhythm and genetic imbalances. A substantial body of research has demonstrated that circadian rhythm plays a significant role in the treatment of autoimmune diseases and neurodegenerative disorders, with increasing attention being directed toward their impact on oral health. Disturbances in circadian rhythm primarily affect psycho-neuro-immune mechanisms, oxidative stress responses, and oral microflora through pathways such as the hypothalamic-pituitary-adrenal axis (HPA axis), brain and muscle ARNT-like 1 (BMAL1)-brain-derived neurotrophic factor (BDNF) signaling, and BMAL1-nuclear factor kappa-B (NF-κB) interactions. These disruptions may influence the progression of oral diseases. Certain pharmacological agents (e.g., melatonin, vitamin D, nobiletin, and propofol) have been shown to regulate mood disorders, immune function, and sleep-wake cycles by upregulating BMAL1 expression, thus alleviating disturbances in circadian rhythm. In addition, non-pharmacological interventions, such as sleep management strategies, psychotherapy approaches, and light therapy, also modulate these processes through HPA axis regulation. Currently, the specific mechanisms by which circadian rhythm regulates BDNF levels, T cell subsets, and inflammatory signals—thereby influencing both pathogenesis and treatment outcomes for oral diseases—remain unclear. Future research should focus on elucidating these molecular mechanisms as well as identifying therapeutic targets related to circadian rhythm within the oral health context. Further, multidisciplinary collaboration encompassing pharmacy, sleep behavior studies, and psychology will be instrumental in advancing prevention strategies and treatments for oral diseases.
- Full text:2025111110134995551昼夜节律在口腔疾病中的作用及防治新策略.pdf
