Research progress of glycoprotein non-metastatic melanoma protein B in lung diseases
10.12025/j.issn.1008-6358.2025.20250236
- VernacularTitle:糖蛋白非转移性黑素瘤蛋白B在肺部疾病中的研究进展
- Author:
Yufeng CHEN
1
;
Huiyi SHEN
2
;
Qing QIN
2
;
Qianyu WANG
1
Author Information
1. Department of Pathology, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian 223800, Jiangsu, China.
2. Department of Nutrition, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
- Publication Type:Review
- Keywords:
glycoprotein non-metastatic melanoma protein B;
lung disease;
therapeutic target
- From:
Chinese Journal of Clinical Medicine
2025;32(4):692-702
- CountryChina
- Language:Chinese
-
Abstract:
Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that plays an important role in various physiological and pathological processes. In recent years, its role in lung diseases has gradually attracted attention. Studies have found that GPNMB is abnormally expressed in lung diseases and is involved in regulating pathological processes such as inflammatory responses, fibrosis, and tumorigenesis. This article systematically reviews the research progress of GPNMB in common lung diseases such as chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, and lung cancer, and explores its potential as a therapeutic target, providing new insights for the diagnosis and treatment of lung diseases in the future.
