Research progress of gastric cancer organoids in chemotherapy drug sensitivity testing
10.12025/j.issn.1008-6358.2025.20240694
- VernacularTitle:胃癌类器官在化疗药物敏感性测定中的研究进展
- Author:
Xinyi YANG
1
;
Yirui YIN
2
;
Zhekun HUANG
2
;
Yanrong YE
3
;
Yun SHEN
3
;
Lumin WANG
4
Author Information
1. Department of Pharmacy, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen 360105, Fujian, China;Department of Pharmacy, Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou 363000, Fujian, China.
2. Department of General Surgery, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen 360105, Fujian, China.
3. Department of Pharmacy, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen 360105, Fujian, China;Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
4. Department of Pharmacy, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen 360105, Fujian, China.
- Publication Type:Review
- Keywords:
gastric cancer;
organoid;
chemotherapy drug;
sensitivity testing;
personalized therapy
- From:
Chinese Journal of Clinical Medicine
2025;32(4):685-691
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer has high incidence and mortality rate. Chemotherapy is the first-line treatment for gastric cancer and has achieved considerable success. However, due to genetic variations and tumor heterogeneity, the effectiveness of chemothrapy drugs varies among different patients. Therefore, accurate assessment of patient’s sensitivity to chemotherapy drugs is crucial for personalized treatment. Gastric cancer organoids serve as effective tools for predicting patient’s sensitivity to chemotherapy drugs. This review summarizes the applications and related research progress of gastric cancer organoids in determining chemotherapy drug sensitivity, discusses the strengths and limitations of organoid models, and proposes outlooks for future research directions, hoping that organoids can provide more effective personalized treatment options and a greater range of drug choices for gastric cancer treatment.
