Progress in diagnosis and treatment of oral and maxillofacial venous malformations
10.12016/j.issn.2096-1456.202550299
- Author:
HOU Jinsong
1
;
ZHANG Yadong
1
;
LIU Haichao
1
Author Information
1. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University
- Publication Type:Journal Article
- Keywords:
oral and maxillofacial region;
venous malformation;
molecular mechanism;
progress in diagnosis and treatment;
imaging manifestations;
sclerotherapy;
surgical treatment;
laser therapy;
targeted therapy;
complication
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(11):919-931
- CountryChina
- Language:Chinese
-
Abstract:
Venous malformation is a common congenital, non-tumor vascular malformation, accounting for about 60% of all vascular malformations, of which 40% occur in the head and neck. Due to the complex anatomical structure of the oral and maxillofacial region and the diverse classification of venous malformations, their clinical treatment poses certain difficulties and challenges. This article systematically elaborates on the etiology, clinical manifestations, imaging features, and clinical treatment strategies of venous malformations in the oral and maxillofacial region. Molecular genetic studies have shown that the occurrence and development of venous malformations are closely related to abnormal activation of the ANGPT/TIE2/PI3K/AKT/mTOR signaling pathway; its clinical manifestations are gradually growing blue purple masses and its histological features are tortuous venous ducts; and clinical imaging examinations have high specificity, among which digital subtraction angiography classification has important clinical guidance value for the treatment of venous malformation sclerosis. According to different classifications, strategies, such as sclerosis treatment, surgical treatment, and laser treatment, can be applied separately or in combination. This article also explores the advantages and disadvantages of targeted therapy in the treatment of venous malformations, with a focus on improving clinical outcomes while reducing complications. At the same time, through the analysis of typical clinical cases, it summarizes the key points of diagnosis and treatment and treatment plans, in order to provide a reference for improving the clinical efficacy of venous malformation treatment and reducing treatment complications.
- Full text:202511071035199585口腔颌面部静脉畸形的诊断与治疗进展.pdf
