Adverse reactions to rabies vaccine for human use in China: a review

Author: ZHAO Zhiyuan ; ZHENG Limin
Publication Type:Journal Article
Keywords: rabies vaccine for human use; adverse reactions; safety
From: Journal of Preventive Medicine 2025;37(7):682-686
CountryChina
Language:Chinese
Abstract: Rabies is an acute infectious disease caused by rabies virus with a high fatality rate. Post-exposure human rabies vaccination is an important measure to reduce the risk of rabies. Rabies vaccine is mainly used for post-exposure immunization with safety and tolerance. However, adverse reactions may occur in some recipients, mainly including local reactions such as pain, redness and swelling, and systemic reactions such as fever and headache. Usually, the symptoms are mild and self-limited, but severe adverse reactions in allergic patients may be life-threatening. The occurrence of adverse reactions to rabies vaccine for human use is closely related to individual differences, vaccine production process, and vaccination factors. The articles on adverse reaction of rabies vaccine for human use published in CNKI and PubMed database from 2006 to 2024 were retrieved. The incidence, causes and countermeasures of adverse reaction of rabies vaccine for human use were reviewed, so as to provide reference for reducing adverse reactions of rabies vaccine.
Full text:2025110609522980261我国人用狂犬病疫苗接种不良反应研究进展.pdf