Research progress on gut microbiome metabolites and depressive disorders
10.19485/j.cnki.issn2096-5087.2025.06.009
- Author:
HE Jingkai
;
HU Jieqiong
;
ZHANG Jiale
;
JI Yunxin
- Publication Type:Journal Article
- Keywords:
depressive disorders;
gut microbiome metabolites;
short-chain fatty acids;
secondary bile acids
- From:
Journal of Preventive Medicine
2025;37(6):583-587
- CountryChina
- Language:Chinese
-
Abstract:
Depressive disorders are common mental illnesses characterized by significant and persistent low mood, with features such as high prevalence, high disability rate, and high suicide rate. The microbiota-gut-brain axis may be one of the potential mechanisms underlying depressive disorders. Gut microbiota metabolites, as important mediators of MGBA signaling, play roles in depressive disorders through multiple pathways. These include short-chain fatty acids, which can regulate the transmission of the vagus nerve, inflammatory responses, and 5-hydroxytryptamine synthesis; secondary bile acids, which can activate farnesoid X receptor and Takeda G protein-compled receptor 5; and choline, which can regulate DNA methylation and trimethylamine N-oxide production. This article reviews the literature on the potential mechanisms of action of gut microbiota metabolites, such as short-chain fatty acids, secondary bile acids, and choline, in depressive disorders. The literature was retrieved from CNKI, PubMed, and Web of Science databases from 2010 to 2025. It aims to provide a theoretical basis for the prevention and treatment of depressive disorders.
- Full text:2025110608301667212肠道菌群代谢产物与抑郁障碍研究进展.pdf
