A case of pericarditis caused by HHV-6B complicated with fulminant diabetes mellitus
- Author:
DING Jie
;
JIN Danqun
;
XU Yuanyuan
- Publication Type:Case Reports
- Keywords:
Human herpes virus 6B;
pericarditis;
fulminant diabetes mellitus;
child
- From:
China Tropical Medicine
2024;24(7):880-
- CountryChina
- Language:Chinese
-
Abstract:
Human herpes virus 6B (HHV-6B) is primarily known for causing primary infections in immunocompetent children, usually presenting as infantile rash. The main symptoms include a high fever lasting 3-5 days followed by a sudden drop in temperature and the emergence of a rash. Generally, the disease is mild and self-limiting. On November 7, 2021, the Pediatric Intensive Care Unit (PICU) of Anhui Children's Hospital admitted a 1-year-3-month-old child infected with HHV-6B. The clinical manifestations of the child mainly included pericardial effusion, shock, and hyperglycemia. Pathogen high-throughput sequencing on pericardial effusion and blood samples confirmed HHV-6B infection, while diabetes-related antibodies, whole genome sequencing, whole exome sequencing, chromosome analysis, and mitochondrial gene testing all yielded normal results. After comprehensive treatment including extraction of pericardial effusion to relieve obstruction for improved cardiac function, fluid resuscitation, vasoactive drugs administration, continuous renal replacement therapy (CRRT), acyclovir antiviral therapy, and insulin control for blood sugar management; the child eventually recovered and was discharged from hospital. Regular follow-ups at the endocrinology department are scheduled every 3-5 months to adjust insulin levels for blood glucose control. According to clinical data and literature review findings indicate that HHV-6B can invade directly and cause immune damage through immune dysregulation, potentially leading to severe outcomes in immunocompetent children.
- Full text:202511051705280168021. A case of pericarditis caused by HHV-6B complicated with fulminant diabetes mellitus.pdf
