Intratumoral Microbiota Promotes Tumor Progression by Modulating Tumor Metabolism
10.3971/j.issn.1000-8578.2025.25.0321
- VernacularTitle:瘤内微生物通过调节肿瘤代谢促进肿瘤进展
- Author:
Yan WANG
1
;
Yi XIE
1
;
Yuhang FANG
1
;
Liyuan FANG
1
;
Ying ZHANG
1
Author Information
1. Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
- Publication Type:REVIEWS
- Keywords:
Malignant tumor;
Intratumoral microbiota;
Tumor metabolism
- From:
Cancer Research on Prevention and Treatment
2025;52(10):855-860
- CountryChina
- Language:Chinese
-
Abstract:
A wealth of prior studies has confirmed that intratumoral microbiota can survive within tumor tissue, thereby promoting or inhibiting tumor growth. With the development of high-throughput sequencing and metabolomics, increasing attention has been paid to the correlation between intratumoral microbiota and host metabolism, and their effect on tumorigenesis and progression. This review focuses on the interaction between intratumoral microbiota and tumor metabolism. It emphasizes the effects of intratumoral microbiota on tumor sugar, lipid, and amino acid metabolism and explores emerging therapeutic strategies for guiding tumor prevention and treatment by modulating tumor metabolism. Although the specific role of intratumoral microbiota in tumor metabolism remains to be further studied, a deepened understanding of the interaction between tumor-specific microbiota and tumor metabolism may provide new directions and application prospects for tumor prevention and treatment.
