Strategies for Optimizing Tumor Physical Microenvironment to Enhance in Situ Vaccine Efficacy
10.3971/j.issn.1000-8578.2025.25.0479
- VernacularTitle:基于优化肿瘤物理微环境的原位疫苗应用策略
- Author:
Han LI
1
;
Xiaolu WANG
1
;
Changhua YU
2
;
Baorui LIU
1
;
Rutian LI
1
Author Information
1. Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
2. Department of Radiotherapy, Huai’an First People’s Hospital, The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an 223300, China.
- Publication Type:REVIEWS
- Keywords:
In situ vaccination;
Immunotherapy;
Tumor physical microenvironment
- From:
Cancer Research on Prevention and Treatment
2025;52(10):840-847
- CountryChina
- Language:Chinese
-
Abstract:
In situ tumor vaccine has become an important strategy in cancer immunotherapy owing to its ability to induce immune responses locally and overcome tumor heterogeneity. However, the abnormal structure and mechanical properties of the tumor’s physical microenvironment significantly limit the efficiency of vaccine delivery and immune efficacy. In this review, the key factors in the tumor’s physical microenvironment, including solid pressure, interstitial fluid pressure, matrix stiffness, and tissue microstructure, are systematically discussed. Their obstructive roles in immune cell infiltration, antigen presentation, and immune activation are analyzed. The potential of approaches, such as radiotherapy, anti-angiogenic therapy, extracellular matrix degradation agents, nanomaterials, and hydrogel delivery platforms, in reshaping the tumor’s physical microenvironment is explored. This review aims to offer theoretical and practical guidance for optimizing in situ vaccine strategies through the regulation of the tumor’s physical microenvironment, ultimately advancing the precision and effectiveness of cancer immunotherapy.
