Follow-up Study on Resolution of Pulmonary Consolidation in 238 Children with Mycoplasma Pneumoniae Pneumonia
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0520
- VernacularTitle:238例儿童肺炎支原体肺炎肺实变吸收情况随访
- Author:
Yuexu OU
1
;
Xiaomin GAN
;
Bin QIN
;
Zhengxiu LUO
;
Jie CAO
Author Information
1. 重庆医科大学附属儿童医院//国家儿童健康与疾病临床医学研究中心//儿童发育疾病研究教育部重点实验室//儿童代谢与炎症性疾病重庆市重点实验室全科医学科,重庆 401122
- Publication Type:Journal Article
- Keywords:
children;
Mycoplasma pneumoniae pneumonia;
lung CT;
pulmonary consolidation volume;
consolidation resolution velocity
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(5):899-906
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To analyze the clinical characteristics and imaging features of effectively treated pediatric Mycoplasma pneumoniae pneumonia(MPP)with pulmonary consolidation,follow up the volume changes of pulmonary consolidation on lung CT scans of the affected children,and investigate the resolution patterns of pulmonary consolidation,and predict the time required for complete resolution.[Methods]We enrolled children with MPP and pulmonary consolidation hospitalized in the Department of General Pediatrics at Children's Hospital of Chongqing Medical University between January 2018 and May 2024.Data collected included demographics,clinical symptoms,laboratory indicators,treatment status,imaging data during hospitalization,as well as follow-up lung CT data and reexamination intervals after discharge.Consolidation volumes were measured before and after the treatment to calculate the resolution rate and resolution velocity.Descriptive statistical analysis was performed on clinical characteristics,imaging features and consolidation resolution.[Results]Among 238 children with MPP and lung consolidation,females slightly outnumbered males(the male to female ratio is 109 vs.129),with a mean age of approximately 5 years.At admission,the median cough and fever durations were 7(5-9)days and 6(4-7)days,respectively.No significant increase was found in white blood cells count or lactate dehydrogenase(LDH),and hypersensitive high-sensitivity C-reactive protein(CRP)slightly increased.Azithromycin was the first line of treatment in most cases,though second-line drugs increased in the recent two years due to the rising resistance.Bronchoalveolar lavage was performed in 66.8%(159/238)of children,and 33.2%(79/238)did not receive lavage.Consolidation was predominantly unilateral(206 unilateral vs.32 bilateral)and right-sided(117 right-sided vs.89 left-sided).The ratio of consolidation volume to total lung volume was 4.48(2.61-7.35)%,the consolidation resolution rate at follow-up was 96.08(88.02-98.95)%,the reexamination interval was 17(15-21)days,the resolution velocity was 2.15(1.23-4.01)cm3/d,and the time to complete resolution was 18.96(16.14-23.33)days.[Conclusions]Pulmonary consolidation in pediatric MPP achieves substantial resolution on CT within 2-3 weeks after effective clinical treatment.Initial consolidation volume and resolution velocity can predict the time required for complete resolution,thereby clinically guiding optimal CT follow-up scheduling.
