Research Progress on the Association Between Ferroptosis and Hypertension
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0504
- VernacularTitle:铁死亡与高血压相关性研究进展
- Author:
Qiyue LIU
1
;
Lijun LIU
2
Author Information
1. Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of Xizang Au-tonomous Region， School of Medicine， Xizang Minzu University， Xianyang 712082， China
2. Key Laboratory of High Altitude Environment and Genes Related to Diseases of Xizang Autonomous Region， School of Medicine， Xizang Minzu University， Xianyang 712082， China
- Publication Type:Journal Article
- Keywords:
hypertension;
ferroptosis;
iron metabolism disorders;
lipid peroxidation;
iron overload
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(5):747-755
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between iron and hypertension has emerged as a significant frontier in cardiovascular research in recent years. Ferroptosis， a newly identified iron-dependent form of regulated cell death， has been demonstrated to play a critical role in the onset and progression of numerous cardiovascular diseases and their related conditions. The core mechanisms of ferroptosis involve dysregulated iron metabolism， lipid peroxidation， and impairment of antioxidant systems， all of which contribute importantly to the pathophysiology of hypertension. Among these， imbalance in iron metabolism and lipid peroxidation are the key drivers of hypertension associated vascular injury， vascular remodeling， and target organ damage. This review systematically summarizes the molecular correlation between ferroptosis and hypertension， focusing on the pathological and physiological mechanisms of iron metabolism disorders and lipid peroxidation， and explores their potential roles in hypertensive pathology. Furthermore， it also analyzes the synergistic physiological and pathological effects for ferroptosis in hypertension. By elucidating the regulatory mechanisms ferroptosis， this work proposes novel perspectives and directions for the early diagnosis and treatment of hypertension， offering a theoretical basis for clinical application. Additionally， therapeutic strategies targeting ferroptosis including iron chelators， antioxidants， and ferroptosis inhibitors are discussed.The aim is to provide a comprehensive and reliable theoretical foundation for future research and to offer innovative ideas for the early diagnosis and intervention of hypertension.
