Mechanism of action of energy metabolism in hepatic ischemia-reperfusion injury and related targeted therapies

VernacularTitle:能量代谢在肝缺血再灌注损伤中的作用机制及靶向治疗
Author: Tiantian YANG ¹ ; Lu HUANG ¹ ; Xiao ZHANG ¹ ; Yali REN ¹ ; Weitian XU ² ; Song ZHANG ²
Author Information

1. School of Medicine， Wuhan University of Science and Technology， Wuhan 430065， China
2. Department of Gastroenterology， General Hospital of Central Theater Command， Wuhan 430012， China
Publication Type:Review
Keywords: Reperfusion Injury; Energy Metabolism; Liver Diseases
From: Journal of Clinical Hepatology 2025;41(9):1956-1960
CountryChina
Language:Chinese
Abstract: Hepatic ischemia-reperfusion injury （HIRI） is an inevitable major complication during surgical procedures such as liver transplantation and partial hepatectomy， and its prevention and treatment are hotspots and difficulties in clinical practice. This article reviews the mechanism of injury caused by energy metabolism disorders during liver ischemia-reperfusion and related treatment strategies and summarizes the current advances in metabolism-related therapies， in order to provide new ideas for further clarifying the onset mechanism of HIRI and exploring effective clinical prevention and treatment strategies for HIRI.