Mechanism of action of the nuclear factor-kappa B signaling pathway in liver diseases and its potential as a therapeutic target
- VernacularTitle:核因子κB信号通路在肝脏疾病中的作用机制及潜在治疗靶点
- Author:
Wenqian FENG
1
;
Yang DU
1
;
Dewen MAO
2
;
Weiyu CHEN
1
;
Lei FU
1
;
Luyi YAN
1
;
Chun YAO
1
;
Yanmei LAN
3
Author Information
- Publication Type:Review
- Keywords: NF-kappa B; Liver Diseases; Signal Pathway
- From: Journal of Clinical Hepatology 2025;41(9):1949-1955
- CountryChina
- Language:Chinese
- Abstract: Nuclear factor-kappa B （NF-κB） is an important intracellular transcription factor widely involved in the processes such as immune response， inflammatory response， cell proliferation， and apoptosis. The abnormal activation of the NF-κB signaling pathway plays a pivotal role in various liver diseases including chronic hepatitis， liver fibrosis， liver cirrhosis， and hepatocellular carcinoma. Extensive studies have shown that inhibiting NF-κB activity may effectively reduce inflammation and fibrosis and improve metabolic disorders. Several natural compounds， such as matrine and salvianolic acid B， have shown the potential in suppressing NF-κB activity， thereby exerting anti-inflammatory， anti-fibrotic， and anti-tumor effects. This article systematically reviews the critical role of the NF-κB signaling pathway in liver diseases and its potential as a therapeutic target， in order to highlight its potential as a therapeutic target for liver diseases and provide new directions for the treatment of liver diseases.
