Mechanisms of aryl hydrocarbon receptor in liver diseases
- VernacularTitle:芳香烃受体在肝脏疾病中的作用及其机制
- Author:
Jing QIN
1
;
Zhilong HE
1
;
Yu LIU
1
;
Kai HU
1
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; Aryl Hydrocarbon Receptor; Therapeutics
- From: Journal of Clinical Hepatology 2025;41(9):1943-1948
- CountryChina
- Language:Chinese
- Abstract: Aryl hydrocarbon receptor （AhR） plays an important role in the development and progression of liver diseases. This article elaborates on the structure of AhR and its function in liver development and provides a detailed analysis of its molecular mechanisms in diseases such as metabolic associated fatty liver disease， alcoholic liver disease， viral hepatitis， drug-induced liver injury， autoimmune hepatitis， liver cirrhosis， and liver cancer. This article also reviews the research advances in AhR agonists and antagonists and analyzes their potential application prospects in disease treatment. At the same time， it points out that although AhR is a promising therapeutic target， there are still various challenges in its clinical application. It is suggested that future research should focus on developing AhR modulators with high specificity and low toxicity and further explore its mechanism of action in different liver diseases.
