Role of mitochondrial division/fusion in different liver diseases
- VernacularTitle:线粒体动力学失衡在不同肝病中的作用
- Author:
Yuanqian MIN
1
;
Shan LI
2
;
Xianghua LIU
3
;
Yi YANG
2
;
Baoping LU
4
Author Information
- Publication Type:Review
- Keywords: Mitochondria; Fatty Liver; Hepatic Fibrosis; Carcinoma， Hepatocellular
- From: Journal of Clinical Hepatology 2025;41(9):1937-1942
- CountryChina
- Language:Chinese
- Abstract: Mitochondria are abundant in hepatocytes and play an important role in the normal operation of the liver. Mitochondrial division/fusion is two biological processes that maintain the dynamic balance of mitochondria， and it is closely associated with the change of cell function and the development and progression of diseases. Balance of mitochondrial division/fusion is of key significance in the treatment of many diseases. Recent studies have shown that abnormal mitochondrial division/fusion plays a significant role in fatty liver disease， hepatitis， liver fibrosis， and liver cancer， which are the four stages of the progression of liver diseases， and the therapeutic targets based on the regulation of such abnormalities are constantly being identified. By reviewing the role of mitochondrial division/fusion in different stages of liver disease， this article further demonstrates the role of mitochondrial division/fusion mechanism in chronic liver diseases and also provides a scientific basis for more ideas on the treatment， remission or even reversal of liver disease progression based on mitochondrial division/fusion.
