Application of three-dimensional hepatocyte models in drug-induced liver injury
- VernacularTitle:三维肝细胞模型在药物性肝损伤中的应用
- Author:
Ziting LI
1
;
Ke ZHANG
1
;
Feng ZHAO
1
;
Yinling MA
1
Author Information
- Publication Type:Review
- Keywords: Chemical and Drug Induced Liver Injury; Models， Biological; Cell Culture Techniques
- From: Journal of Clinical Hepatology 2025;41(9):1931-1936
- CountryChina
- Language:Chinese
- Abstract: Drug-induced liver injury （DILI） is the main cause of failures in drug development and the withdrawal of approved drugs from the market， and therefore， there is an increasing demand for accurate prediction and in vitro testing. However， the two-dimensional cell culture system of hepatocytes is not suitable for the toxicity study of long-term drug use due to the fact that it cannot accurately simulate and reproduce the real environment and micro-ecosystem of hepatocytes in vivo. In view of this， there is an urgent need for liver models with higher predictability to assess the hepatotoxicity of drugs in drug development and the safety evaluation of active compounds. This article reviews the construction and application of three-dimensional in vitro hepatocyte culture systems for DILI， in order to provide a reference for their effective implementation in DILI analysis.
