Gene therapy for hepatocellular carcinoma： Current research status and challenges
- VernacularTitle:肝细胞癌基因治疗： 现状及挑战
- Author:
Huimin DOU
1
;
Wanxiang WANG
2
Author Information
- Publication Type:Review
- Keywords: Carcinoma， Hepatocellular; Genetic Therapy; Therapeutics
- From: Journal of Clinical Hepatology 2025;41(9):1920-1924
- CountryChina
- Language:Chinese
- Abstract: Hepatocellular carcinoma （HCC） is one of the most common malignant tumors worldwide， and most patients are in the advanced stage at the time of diagnosis， leading to a poor prognosis and a low survival rate. Traditional treatment methods often have limited efficacy， while gene therapy， as an emerging therapeutic strategy， has shown great potential with numerous challenges. This article mainly introduces the latest advances in the field of gene therapy for HCC and analyzes the key issues that need to be addressed in the future development of this field. Gene therapy has become a research hotspot in HCC due to its advantages of strong targeting， diverse mechanisms of action， and individualized treatment. Although gene therapy is still in the exploratory stage in the treatment of HCC， some preliminary research findings have been achieved. According to the reports in the literature， the combination of gene therapy with other treatment methods， such as chemotherapy and immunotherapy， can improve treatment outcomes and reduce the side effects of monotherapy. With the continuous advances in technology， gene therapy is expected to bring new hope to HCC patients.
