Research advances in traditional Chinese medicine for the prevention and treatment of inflammation-to-cancer transformation in chronic hepatitis
- VernacularTitle:中医药防治慢性肝炎“炎癌转化”的研究进展
- Author:
Simiao YU
1
;
Sici WANG
2
;
Haocheng ZHENG
2
;
Yongqiang SUN
1
;
Jing JING
1
;
Tingting HE
1
;
Liping WANG
1
;
Aozhe ZHANG
1
;
Xin WANG
1
;
Xia DING
2
;
Ruilin WANG
1
Author Information
- Publication Type:Review
- Keywords: Liver Neoplasms; Hepatitis， Chronic; Traditional Chinese Medicine and Pharmacy
- From: Journal of Clinical Hepatology 2025;41(9):1888-1895
- CountryChina
- Language:Chinese
- Abstract: Primary liver cancer is one of the most common malignant tumors of the digestive system， and the “inflammation-to-cancer transformation” （ICT） of chronic hepatitis is the core pathological process of the progression of chronic hepatitis to liver cancer. Persistent and uncontrolled liver inflammation in patients with chronic hepatitis often leads to repeated liver tissue damage and repair， which gradually develops into liver fibrosis and cirrhosis， eventually leading to malignant transformation through the mechanisms such as gene mutation and microenvironment imbalance. ICT in chronic hepatitis is the key link between chronic hepatitis and liver cancer， and its dynamic evolution involves various pathogenic factors such as dampness， heat， deficiency， toxin， and stasis； among which damp-heat and vital energy deficiency are the initiating factors for ICT of chronic hepatitis， while intermingled stasis and toxin are the key pathological products that promote malignant transformation. Based on the concept of preventive treatment， traditional Chinese medicine can effectively delay and even block the ICT of chronic hepatitis by regulating inflammation， metabolism， and abnormal cell proliferation through multiple targets， which provides important strategies and research directions for the prevention and treatment of liver cancer.
