Exploring the idea of differentiating and treating mild cognitive impairment due to Alzheimer′s disease based on latent toxin blocking collaterals
10.3969/j.issn.1006-2157.2025.04.014
- VernacularTitle:基于伏毒阻络辨治阿尔茨海默病源性轻度认知障碍的思路探究
- Author:
Hu XI
1
;
Wenming YANG
2
;
Hao LI
3
;
Wenting XIE
4
;
Yue YANG
4
;
Shu ZHAI
4
Author Information
1. Wangjing Hospital, China Academy of Chinese Medical Sciences;The First Affiliated Hospital of Anhui University of Chinese Medicine
2. The First Affiliated Hospital of Anhui University of Chinese Medicine;Key Laboratory of Xin an Medicine, Ministry of Education;Center for Xin an Medicine and Modernization of Traditional Chinese Medicine, Institute of Health and Medicine, Hefei Comprehensive National Science Center
3. Wangjing Hospital, China Academy of Chinese Medical Sciences
4. The First Affiliated Hospital of Anhui University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
latent toxin blocking collaterals;
mild cognitive impairment due to Alzheimer′s disease;
micro-lumps in the brain;
etiology;
pathogenesis;
traditional Chinese medicine treatment based on disease differentiation
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(4):559-565
- CountryChina
- Language:Chinese
-
Abstract:
Mild cognitive impairment due to Alzheimer′s disease is an inevitable pathological stage in the early development of Alzheimer′s disease, which can be classified as "microlumps in the brain collaterals" in traditional Chinese medicine. Based on the theory of latent toxin blocking collaterals, this article discusses the etiology and pathogenesis, clinical sequelae, and traditional Chinese medicine intervention strategies for mild cognitive impairment due to Alzheimer′s disease. The onset of mild cognitive impairment due to Alzheimer′s disease is very similar to the latent pathogen theory, which states that "the latent pathogen is latent and then develops, the poison is deep and difficult to cure, and the development can be recognized but the latent pathogen cannot be detected." Combining clinical experience, our team believes that the basic nature of the disease is a slight deficiency and a slight excess of symptoms. A slight deficiency of the five zang viscera and six fu viscera as root and a latent toxin colling collaterals of qi, fire, phlegm, and blood stasis as manifestaion. These usually start from the qi depression and develop into phlegm coagulation and blood stasis, then end up in latent toxin and gradually become the healthy qi deficiency. Therefore, the deficiency of vital qi and incubation of evil, latent toxin blocking collaterals the pathogenesis of early intervention of this disease should be carried out, upholding the idea that "the upper workman treats the disease before it is diagnosed." The principle of strengthening vital qi to eliminate pathogenic factors, slowing down and promoting pathogenic factors elimination, establishing the method of supporting correctness and wisdom, simultaneously detoxifying and clearing the blood stasis, pattern differentiation as the main and the disease differentiation as the first, combining the disease and pattern, and adjusting the macroscopic and microscopic, focusing simultaneously on eliminating and replenishing, dispel phlegm and remove blood stasis, achieve a strong vital qi and the elimination of evil, and enhance intelligence, delay or even block the progression of mild cognitive impairment due to Alzheimer′s disease, improve patients′ quality of life, and provide a theoretical basis for the early clinical prevention and treatment of Alzheimer′s disease.
- Full text:202510291023536326Exploring the idea of differentiating and treating mild cognitive impairment due to Alzheimer′s disease based on latent toxin blocking collaterals.pdf
