Diagnostic value of CD4+T cells combined with interleukin-8 in human immunodeficiency virus-associated cytomegalovirus retinitis
10.3980/j.issn.1672-5123.2025.11.22
- VernacularTitle:CD4+T细胞联合IL-8对HIV相关巨细胞病毒性视网膜炎的诊断价值
- Author:
Qi AN
1
;
Ye YING
1
;
Yan XU
1
;
Hao HONG
1
Author Information
1. Department of Ophthalmology, Second Hospital of Nanjing, Nanjing 210003, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
cytomegalovirus retinitis;
human immunodeficiency virus(HIV);
interleukin-8(IL-8);
CD4+T cells;
diagnostic value
- From:
International Eye Science
2025;25(11):1854-1858
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the diagnostic value of CD4+T cells combined with interleukin-8(IL-8)in human immunodeficiency virus(HIV)-associated cytomegalovirus retinitis(CMVR).METHODS: A retrospective study was conducted on 80 HIV-infected patients who visited the Second Hospital of Nanjing from June 2021 to December 2024, including 51 males and 29 females, aged from 22 to 56(44.25±6.31)years, and they were divided into CMVR group(49 cases)and non-CMVR group(31 cases)based on whether the patients had CMVR. The clinical data of the two groups were compared. Restricted cubic spline analysis was performed to analyze the dose-response relationship between CD4+ T cells, IL-8 and the risk of CMVR in HIV-infected patients. Receiver operating characteristic(ROC)curves were used to analyze the diagnostic value of CD4+T cells and IL-8 alone or in combination for HIV-associated CMVR.RESULTS: The IL-8 level in the CMVR group was significantly higher than that in the non-CMVR group, while the levels of neutrophils, neutrophil to lymphocyte ratio(NLR), and CD4+T cells were significantly lower than the non-CMVR group(all P<0.05). The results of restrictive cubic spline analysis showed that there was a significant nonlinear relationship between IL-8, CD4+T cells and the risk of CMVR(Chi-Square=13.625, 5.406, P=0.001, 0.045). The areas under the ROC curve for IL-8 and CD4+ alone and in combination were 0.777, 0.743 and 0.836, respectively.CONCLUSION: Both IL-8 and CD4+T cells showed good diagnostic value for HIV-related CMVR, and their combination further enhances diagnostic efficiency.
