Research progress on peripheral defocus-based optical interventions combined with other therapies for myopia control
10.3980/j.issn.1672-5123.2025.11.16
- VernacularTitle:周边离焦光学干预联合其他疗法在近视控制的研究进展
- Author:
Xiaoqing LIU
1
;
Jinhai ZHONG
1
;
Quan LIN
1
Author Information
1. Aier Eye Hospital, Jinan University, Guangzhou 510071, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
combination therapy;
defocus-based optical interventions;
low-concentration atropine;
repeated low-level red-light therapy;
visual training;
myopia control
- From:
International Eye Science
2025;25(11):1814-1819
- CountryChina
- Language:Chinese
-
Abstract:
The global myopia epidemic presents a significant public health challenge, necessitating diverse intervention strategies. The primary objective of myopia management is to achieve a dual therapeutic effect: providing children with clear, comfortable, and sustained vision, while also curbing rapid myopic progression to prevent high myopia. Optical interventions based on the theory of peripheral retinal defocus have become first-line treatments owing to their dual capacity for vision correction and axial elongation control. For children with myopia who show suboptimal response to defocus-based optical interventions, combination therapy has gradually emerged as a new clinical trend. Current combination strategies primarily include defocus-based optical interventions combined with low-concentration atropine, red-light therapy, and vision training, among others. This review summarizes available evidence on these three combination strategies, focusing on clinical efficacy, safety, and underlying mechanisms, with the aim of supporting evidence-based and personalized myopia management plans for clinicians.
