Research progress on post-translational modifications of proteins in diabetic retinopathy
10.3980/j.issn.1672-5123.2025.11.13
- VernacularTitle:蛋白翻译后修饰在糖尿病视网膜病变中的研究进展
- Author:
Haoyu YAO
1
;
Wenjun ZOU
1
Author Information
1. Wuxi No.2 People's Hospital;Jiangnan University Medical Center, Wuxi 214001, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
post-translational modifications;
molecular mechanism;
review
- From:
International Eye Science
2025;25(11):1797-1801
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR), a major microvascular complication of diabetes, is driven by hyperglycemia-induced oxidative stress, chronic inflammation, and neurodegeneration. Post-translational modifications(PTM)play pivotal roles in DR progression by dynamically regulating protein functions. Key PTMs, including phosphorylation, acetylation, ubiquitination, and O-glcNAcylation, collectively exacerbate vascular dysfunction, inflammatory responses, metabolic dysregulation, and neuronal damage. The intricate crosstalk among PTM underscores the multifaceted pathology of DR. Future research should focus on elucidating PTM interaction networks, developing targeted modulators, and leveraging advanced technologies to uncover their roles in retinal cellular heterogeneity, thereby advancing precision therapeutic strategies for DR.
