Innovative design and research progress of liposomes in ocular drug delivery
10.3980/j.issn.1672-5123.2025.11.10
- VernacularTitle:脂质体在眼科药物递送中的创新设计与研究进展
- Author:
Xiaoyun DONG
1
;
Jike SONG
1
;
Hongsheng BI
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China; Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine;Shandong Academy of Eye Disease Prevention and Therapy;Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Jinan 250002, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
liposomes;
drug delivery;
ophthalmic diseases
- From:
International Eye Science
2025;25(11):1777-1784
- CountryChina
- Language:Chinese
-
Abstract:
The complex anatomical structure and physiological barriers of the eye present substantial challenges for local drug delivery, leading to suboptimal ocular drug bioavailability, which typically remains below 5% in conventional ophthalmic formulations. Frequent or high-dose administration not only increases the treatment burden but also heightens the risk of both local and systemic adverse effects. Liposomes, as an advanced drug delivery system, enhance ocular bioavailability through their biocompatibility and targeted delivery properties. Recent innovations in surface modification and functionalization have further enhanced their ability to overcome ocular barriers and facilitate controlled drug release. Liposome-based formulations have demonstrated significant therapeutic potential for diseases such as glaucoma and dry eye syndrome. Drawing on the research advancements over the past 5 a, this article systematically reviews the innovative design strategies and applications of liposomes in ocular drug delivery, with the aim of providing theoretical basis and technical reference for the development of new ophthalmic drugs.
