Immune-metabolic regulatory mechanism of the gut-eye axis of intestinal flora in dry eye and new treatment strategies
10.3980/j.issn.1672-5123.2025.11.09
- VernacularTitle:肠道菌群在干眼中的肠-眼轴免疫代谢调控机制及治疗新策略
- Author:
Xiaotong LIU
1
;
Xinyi SUN
1
;
Weiping GAO
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
dry eye;
gut-eye axis;
gut microbiome;
ocular surface microbes;
metabolite
- From:
International Eye Science
2025;25(11):1771-1776
- CountryChina
- Language:Chinese
-
Abstract:
Dry eye disease is a multifactorial chronic ocular surface disorder that is challenging to manage because its pathogenesis is not well understood. The gut-eye axis theory provides insights into its pathogenesis to guide prevention and treatment. Intestinal flora dysbiosis induces dry eye disease through complex mechanisms involving inflammation, ocular surface microbiota, nerve damage, and microbial metabolites. This article reviews the immunometabolic regulation of the gut-eye axis and summarizes gut flora-targeted interventions(fecal microbiota transplantation, probiotic supplementation, and dietary modification)to provide a theoretical basis for dry eye disease prevention and treatment.
