Pharmacological Mechanism of Traditonal Chinese Medicine in Prevention and Treatment of Breast Cancer： A Review
10.13422/j.cnki.syfjx.20250129
- VernacularTitle:中医药防治乳腺癌的药理作用机制研究进展
- Author:
Xiaoli WEN
1
;
Fangyan CAI
2
;
Biting CHENG
1
;
Xiang ZHANG
1
;
Hongning LIU
1
Author Information
1. Jiangxi University of Chinese Medicine，Nanchang 330004，China
2. Nanchang Medical College，Nanchang 330052，China
- Publication Type:Review
- Keywords:
traditional Chinese medicine;
prevention and treatment;
breast cancer;
pharmacological effect;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(22):252-263
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer， as one of the major cancers threatening women's health globally， is characterized by high aggressiveness， high malignancy， and poor prognosis. In 2022， according to the World Health Organization， breast cancer ranked second in the incidence of female cancers globally， accounting for 11.6% of all new cancer cases. Western medical doctors mainly use surgery， chemotherapy， radiotherapy， endocrine therapy， and molecular targeted therapy to treat breast cancer， which can effectively improve the recurrence rate and death rate of breast cancer patients and prolong the survival period of patients. However， its treatment process is often accompanied by a series of side effects， which bring challenges to patients' quality of life. However， traditional Chinese medicine （TCM） has demonstrated significant therapeutic effects in inhibiting the proliferation and metastasis of breast cancer cells， reducing toxic side effects produced by chemotherapy， and improving patients' survival rate and quality of life. It is therefore particularly necessary to investigate the pharmacological effects and mechanisms of TCM in breast cancer treatment. The authors combed the pharmacological effects and mechanisms of the etiology and pathogenesis of breast cancer， identification and treatment of breast cancer， TCM compound， TCM single medicine， TCM monomer， and external treatment of TCM to prevent and control breast cancer and found that TCM has a therapeutic effect on breast cancer. It can play a role in increasing the effectiveness， reducing the toxicity， and alleviating the adverse reactions. It can inhibit breast cancer cell proliferation， cell cycle， migration， invasion， immune escape， epithelial-mesenchymal transition （EMT）， aerobic glycolysis， mitochondrial biosynthesis， aminoacyl-tRNA biosynthesis， reduce drug resistance， promote apoptosis， ferroptosis， cell autophagy， and regulate the tumor immune microenvironment by regulating signaling pathways. This paper aims to provide new ideas and methods for experimental research and clinical treatment of breast cancer.
