Animal Models of Carotid Vulnerable Plaques Based on Clinical Disease and Syndrome Characteristics of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20251337
- VernacularTitle:基于中西医临床病证特点的颈动脉易损斑块动物模型分析
- Author:
Yuzhi JIA
1
;
Qingyong HE
1
;
Ziyi WANG
1
;
Suwen CHEN
1
;
Hui ZHANG
1
;
Jing GAO
1
;
Peihao WANG
1
;
Junqiao AN
1
Author Information
1. Guang'anmen Hospital， Chinese Academy of traditional Chinese medicine，Beijing 100053，China
- Publication Type:Journal Article
- Keywords:
carotid vulnerable plaque;
disease and syndrome combination of traditional Chinese medicine and western medicine;
animal models;
evaluation and analysis;
characteristics of disease and syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(22):235-240
- CountryChina
- Language:Chinese
-
Abstract:
The rupture of carotid vulnerable plaques is the core pathological basis for major cardiovascular and cerebrovascular events. However， the insufficient alignment between existing animal models and the clinical disease and syndrome characteristics of traditional Chinese and western medicine has limited research progress. In this study， biomedical databases in China and abroad were systematically searched， and the modeling mechanisms and evaluation systems of carotid vulnerable plaque animal models were systematically assessed based on diagnostic criteria of both traditional Chinese and western medicine. Analysis of the clinical correspondence indicated that existing animal models can be categorized into four types： simple high-fat diet， surgical induction combined with high-fat feeding， genetic engineering combined with high-fat feeding， and drug induction combined with high-fat feeding. Among these， the compound strategy of surgical induction combined with high-fat feeding has become the current mainstream approach， showing good concordance with western medicine. The study found that the double balloon injury rabbit model and the ApoE-/- mouse carotid artery tandem constriction combined with high-fat feeding model demonstrated a high degree of clinical correspondence with both traditional Chinese and western medicine in terms of vulnerable plaque imaging and pathological features. Nevertheless， existing models still face significant technical limitations in faithfully simulating plaque pathology and in translating findings to clinical applications. To address these challenges， integrating complex comorbidity mechanism construction， multimodal dynamic mechanism monitoring， and collaborative evaluation systems of traditional Chinese and western medicine could enable the development of highly concordant carotid vulnerable plaque disease-syndrome combination animal models. Such models would provide a reproducible experimental platform for targeted drug development to regulate plaque stability and for individualized precision treatment， as well as a theoretical basis for innovation in clinical diagnostic and therapeutic strategies.
